Optimizing Fertility in Primary Ovarian Insufficiency: Case Report and Literature Review

Primary ovarian insufficiency (POI) is a clinical spectrum of dysfunction. Overt POI presents with oligo/amenorrhea and hypergonadotropic hypogonadism before age 40 years. involves chronic health problems to include increased morbidity mortality related estradiol deficiency the associated osteoporosis cardiovascular disease as well psychological psychiatric disorders loss reproductive hormones infertility. Presently, standard testing, mechanism for can only be identified in about 10% cases. Now discovery new mechanisms permits an etiology research setting 25–30% overt The most common genetic cause premutation FMR1 . infertility life altering. Oocyte donation effective, although many women prefer conceive their own ova. Surprisingly, majority who have still detectable follicles (70%). major follicle dysfunction has been histologically defined by prospective NIH study: inappropriate luteinization due tonically elevated serum LH levels. A trial physiologic hormone replacement therapy, clinically proven suppress levels these women, may improve function increase chance ovulation. Here, we report case woman diagnosed at 35 To attempt pregnancy, she elected intrauterine insemination (IUI) conjunction monitoring therapy. She conceived on eighth cycle treatment delivered healthy baby. Our calls concerted effort define best methods which optimize fertility POI.